M4 mAChR-Mediated Modulation of Glutamatergic Transmission at Corticostriatal Synapses
نویسندگان
چکیده
منابع مشابه
Activation of cAMP-dependent protein kinase suppresses the presynaptic cannabinoid inhibition of glutamatergic transmission at corticostriatal synapses.
In a previous study, we showed that type 1 cannabinoid (CB(1)) receptor activation substantially depresses the corticostriatal glutamatergic transmission onto striatal neurons in the brain slice preparation. We now report that the adenylyl cyclase activator forskolin and cAMP analog (S)-p-8-(4-chlorophenythil) adenosine-3',5'-monophosphorothioate (Sp-8-CPT-cAMPS) strongly suppressed the synapti...
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ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2014
ISSN: 1948-7193,1948-7193
DOI: 10.1021/cn500003z